Metagenomic Analysis of Taxa Associated with Lutzomyia longipalpis, Vector of Visceral Leishmaniasis, Using an Unbiased High-Throughput Approach
Identifieur interne : 001694 ( Main/Exploration ); précédent : 001693; suivant : 001695Metagenomic Analysis of Taxa Associated with Lutzomyia longipalpis, Vector of Visceral Leishmaniasis, Using an Unbiased High-Throughput Approach
Auteurs : Christina B. Mccarthy [Argentine] ; Luis A. Diambra [Argentine] ; Rolando V. Rivera Pomar [Argentine]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2011.
Abstract
Leishmaniasis is one of the most diverse and complex of all vector-borne diseases worldwide. It is caused by parasites of the genus
An inventory of the microbiota associated with insect vectors, especially of wild specimens, would aid in the development of novel strategies for controlling insect vectors. Given the recent VL outbreak in Argentina and the compelling need to develop appropriate control strategies, this study focused on wild male and female
This is the first time an unbiased and comprehensive metagenomic approach has been used to survey taxa associated with an infectious disease vector. The identification of gregarines suggested they are a possible efficient control method under natural conditions. Ongoing studies are determining the significance of the associated taxa found in this study in a greater number of adult male and female
Url:
DOI: 10.1371/journal.pntd.0001304
PubMed: 21909446
PubMed Central: 3167787
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Metagenomic Analysis of Taxa Associated with <italic>Lutzomyia longipalpis</italic>, Vector of Visceral Leishmaniasis, Using an Unbiased High-Throughput Approach</title><author><name sortKey="Mccarthy, Christina B" sort="Mccarthy, Christina B" uniqKey="Mccarthy C" first="Christina B." last="Mccarthy">Christina B. Mccarthy</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina</addr-line></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino, Buenos Aires, Argentina</addr-line></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Diambra, Luis A" sort="Diambra, Luis A" uniqKey="Diambra L" first="Luis A." last="Diambra">Luis A. Diambra</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina</addr-line></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Rivera Pomar, Rolando V" sort="Rivera Pomar, Rolando V" uniqKey="Rivera Pomar R" first="Rolando V." last="Rivera Pomar">Rolando V. Rivera Pomar</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina</addr-line></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino, Buenos Aires, Argentina</addr-line></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21909446</idno><idno type="pmc">3167787</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167787</idno><idno type="RBID">PMC:3167787</idno><idno type="doi">10.1371/journal.pntd.0001304</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001095</idno><idno type="wicri:Area/Pmc/Curation">001094</idno><idno type="wicri:Area/Pmc/Checkpoint">000E32</idno><idno type="wicri:Area/Ncbi/Merge">000E17</idno><idno type="wicri:Area/Ncbi/Curation">000E17</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E17</idno><idno type="wicri:doubleKey">1935-2727:2011:Mccarthy C:metagenomic:analysis:of</idno><idno type="wicri:Area/Main/Merge">001716</idno><idno type="wicri:Area/Main/Curation">001694</idno><idno type="wicri:Area/Main/Exploration">001694</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Metagenomic Analysis of Taxa Associated with <italic>Lutzomyia longipalpis</italic>, Vector of Visceral Leishmaniasis, Using an Unbiased High-Throughput Approach</title><author><name sortKey="Mccarthy, Christina B" sort="Mccarthy, Christina B" uniqKey="Mccarthy C" first="Christina B." last="Mccarthy">Christina B. Mccarthy</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina</addr-line></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino, Buenos Aires, Argentina</addr-line></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Diambra, Luis A" sort="Diambra, Luis A" uniqKey="Diambra L" first="Luis A." last="Diambra">Luis A. Diambra</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina</addr-line></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Rivera Pomar, Rolando V" sort="Rivera Pomar, Rolando V" uniqKey="Rivera Pomar R" first="Rolando V." last="Rivera Pomar">Rolando V. Rivera Pomar</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina</addr-line></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino, Buenos Aires, Argentina</addr-line></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Leishmaniasis is one of the most diverse and complex of all vector-borne diseases worldwide. It is caused by parasites of the genus <italic>Leishmania</italic>, obligate intramacrophage protists characterised by diversity and complexity. Its most severe form is visceral leishmaniasis (VL), a systemic disease that is fatal if left untreated. In Latin America VL is caused by <italic>Leishmania infantum chagasi</italic> and transmitted by <italic>Lutzomyia longipalpis</italic>. This phlebotomine sandfly is only found in the New World, from Mexico to Argentina. In South America, migration and urbanisation have largely contributed to the increase of VL as a public health problem. Moreover, the first VL outbreak was recently reported in Argentina, which has already caused 7 deaths and 83 reported cases.</p></sec><sec><title>Methodology/Principal Findings</title><p>An inventory of the microbiota associated with insect vectors, especially of wild specimens, would aid in the development of novel strategies for controlling insect vectors. Given the recent VL outbreak in Argentina and the compelling need to develop appropriate control strategies, this study focused on wild male and female <italic>Lu. longipalpis</italic> from an Argentine endemic (Posadas, Misiones) and a Brazilian non-endemic (Lapinha Cave, Minas Gerais) VL location. Previous studies on wild and laboratory reared female <italic>Lu. longipalpis</italic> have described gut bacteria using standard bacteriological methods. In this study, total RNA was extracted from the insects and submitted to high-throughput pyrosequencing. The analysis revealed the presence of sequences from bacteria, fungi, protist parasites, plants and metazoans.</p></sec><sec><title>Conclusions/Significance</title><p>This is the first time an unbiased and comprehensive metagenomic approach has been used to survey taxa associated with an infectious disease vector. The identification of gregarines suggested they are a possible efficient control method under natural conditions. Ongoing studies are determining the significance of the associated taxa found in this study in a greater number of adult male and female <italic>Lu. longipalpis</italic> samples from endemic and non-endemic locations. A particular emphasis is being given to those species involved in the biological control of this vector and to the etiologic agents of animal and plant diseases.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Desjeux, P" uniqKey="Desjeux P">P Desjeux</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Collin, Sm" uniqKey="Collin S">SM Collin</name></author><author><name sortKey="Coleman, Pg" uniqKey="Coleman P">PG Coleman</name></author><author><name sortKey="Ritmeijer, K" uniqKey="Ritmeijer K">K Ritmeijer</name></author><author><name sortKey="Davidson, Rn" uniqKey="Davidson R">RN Davidson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, Sp" uniqKey="Singh S">SP Singh</name></author><author><name sortKey="Reddy, Dc" uniqKey="Reddy D">DC Reddy</name></author><author><name sortKey="Rai, M" uniqKey="Rai M">M Rai</name></author><author><name sortKey="Sundar, S" uniqKey="Sundar S">S Sundar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, U" uniqKey="Sharma U">U Sharma</name></author><author><name sortKey="Singh, S" uniqKey="Singh S">S Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grimaldi, G" uniqKey="Grimaldi G">G Grimaldi</name></author><author><name sortKey="Tesh, Rb" uniqKey="Tesh R">RB Tesh</name></author><author><name sortKey="Mcmahon Pratt, D" uniqKey="Mcmahon Pratt D">D McMahon-Pratt</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Salomon, Od" uniqKey="Salomon O">OD Salomon</name></author><author><name sortKey="Rossi, G" uniqKey="Rossi G">G Rossi</name></author><author><name sortKey="Sosa Estani, S" uniqKey="Sosa Estani S">S Sosa Estani</name></author><author><name sortKey="Spinelli, G" uniqKey="Spinelli G">G Spinelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salomon, O" uniqKey="Salomon O">O Salomon</name></author><author><name sortKey="Sinagra, A" uniqKey="Sinagra A">A Sinagra</name></author><author><name sortKey="Nevot, M" uniqKey="Nevot M">M Nevot</name></author><author><name sortKey="Barberian, G" uniqKey="Barberian G">G Barberian</name></author><author><name sortKey="Paulin, P" uniqKey="Paulin P">P Paulin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferro, C" uniqKey="Ferro C">C Ferro</name></author><author><name sortKey="Pardo, R" uniqKey="Pardo R">R Pardo</name></author><author><name sortKey="Torres, M" uniqKey="Torres M">M Torres</name></author><author><name sortKey="Morrison, Ac" uniqKey="Morrison A">AC Morrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cameron, Mm" uniqKey="Cameron M">MM Cameron</name></author><author><name sortKey="Pessoa, Fa" uniqKey="Pessoa F">FA Pessoa</name></author><author><name sortKey="Vasconcelos, Aw" uniqKey="Vasconcelos A">AW Vasconcelos</name></author><author><name sortKey="Ward, Rd" uniqKey="Ward R">RD Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaniotis, Bn" uniqKey="Chaniotis B">BN Chaniotis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dillon, Rj" uniqKey="Dillon R">RJ Dillon</name></author><author><name sortKey="Dillon, Vm" uniqKey="Dillon V">VM Dillon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steinhaus, Ea" uniqKey="Steinhaus E">EA Steinhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez Ceron, L" uniqKey="Gonzalez Ceron L">L Gonzalez-Ceron</name></author><author><name sortKey="Santillan, F" uniqKey="Santillan F">F Santillan</name></author><author><name sortKey="Rodriguez, Mh" uniqKey="Rodriguez M">MH Rodriguez</name></author><author><name sortKey="Mendez, D" uniqKey="Mendez D">D Mendez</name></author><author><name sortKey="Hernandez Avila, Je" uniqKey="Hernandez Avila J">JE Hernandez-Avila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kishore, K" uniqKey="Kishore K">K Kishore</name></author><author><name sortKey="Kumar, V" uniqKey="Kumar V">V Kumar</name></author><author><name sortKey="Kesari, S" uniqKey="Kesari S">S Kesari</name></author><author><name sortKey="Dinesh, Ds" uniqKey="Dinesh D">DS Dinesh</name></author><author><name sortKey="Kumar, Aj" uniqKey="Kumar A">AJ Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deane, L" uniqKey="Deane L">L Deane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gouveia, C" uniqKey="Gouveia C">C Gouveia</name></author><author><name sortKey="Asensi, Md" uniqKey="Asensi M">MD Asensi</name></author><author><name sortKey="Zahner, V" uniqKey="Zahner V">V Zahner</name></author><author><name sortKey="Rangel, Ef" uniqKey="Rangel E">EF Rangel</name></author><author><name sortKey="Oliveira, Sm" uniqKey="Oliveira S">SM Oliveira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oliveira, Sm" uniqKey="Oliveira S">SM Oliveira</name></author><author><name sortKey="Moraes, Ba" uniqKey="Moraes B">BA Moraes</name></author><author><name sortKey="Goncalves, Ca" uniqKey="Goncalves C">CA Goncalves</name></author><author><name sortKey="Giordano Dias, Cm" uniqKey="Giordano Dias C">CM Giordano-Dias</name></author><author><name sortKey="D Almeida, Jm" uniqKey="D Almeida J">JM D'Almeida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perira De Oliveira, Sm" uniqKey="Perira De Oliveira S">SM Perira de Oliveira</name></author><author><name sortKey="De Morais, Ba" uniqKey="De Morais B">BA de Morais</name></author><author><name sortKey="Goncalves, Ca" uniqKey="Goncalves C">CA Goncalves</name></author><author><name sortKey="Giordano Dias, Cm" uniqKey="Giordano Dias C">CM Giordano-Dias</name></author><author><name sortKey="Vilela, Ml" uniqKey="Vilela M">ML Vilela</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="La Scola, B" uniqKey="La Scola B">B La Scola</name></author><author><name sortKey="Raoult, D" uniqKey="Raoult D">D Raoult</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zayed, Me" uniqKey="Zayed M">ME Zayed</name></author><author><name sortKey="Bream, As" uniqKey="Bream A">AS Bream</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindh, Jm" uniqKey="Lindh J">JM Lindh</name></author><author><name sortKey="Terenius, O" uniqKey="Terenius O">O Terenius</name></author><author><name sortKey="Faye, I" uniqKey="Faye I">I Faye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rani, A" uniqKey="Rani A">A Rani</name></author><author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name></author><author><name sortKey="Rajagopal, R" uniqKey="Rajagopal R">R Rajagopal</name></author><author><name sortKey="Adak, T" uniqKey="Adak T">T Adak</name></author><author><name sortKey="Bhatnagar, Rk" uniqKey="Bhatnagar R">RK Bhatnagar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schlein, Y" uniqKey="Schlein Y">Y Schlein</name></author><author><name sortKey="Polacheck, I" uniqKey="Polacheck I">I Polacheck</name></author><author><name sortKey="Yuval, B" uniqKey="Yuval B">B Yuval</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, D" uniqKey="Young D">D Young</name></author><author><name sortKey="Duncan, M" uniqKey="Duncan M">M Duncan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tesh, Rb" uniqKey="Tesh R">RB Tesh</name></author><author><name sortKey="Boshell, J" uniqKey="Boshell J">J Boshell</name></author><author><name sortKey="Modi, Gb" uniqKey="Modi G">GB Modi</name></author><author><name sortKey="Morales, A" uniqKey="Morales A">A Morales</name></author><author><name sortKey="Young, Dg" uniqKey="Young D">DG Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Travassos Da Rosa, Ap" uniqKey="Travassos Da Rosa A">AP Travassos da Rosa</name></author><author><name sortKey="Tesh, Rb" uniqKey="Tesh R">RB Tesh</name></author><author><name sortKey="Travassos Da Rosa, Jf" uniqKey="Travassos Da Rosa J">JF Travassos da Rosa</name></author><author><name sortKey="Herve, Jp" uniqKey="Herve J">JP Herve</name></author><author><name sortKey="Main, Aj" uniqKey="Main A">AJ Main</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warburg, A" uniqKey="Warburg A">A Warburg</name></author><author><name sortKey="Pimenta, Pf" uniqKey="Pimenta P">PF Pimenta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lainson, R" uniqKey="Lainson R">R Lainson</name></author><author><name sortKey="Rangel, Ef" uniqKey="Rangel E">EF Rangel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lainson, R" uniqKey="Lainson R">R Lainson</name></author><author><name sortKey="Killick Kendrick, R" uniqKey="Killick Kendrick R">R Killick-Kendrick</name></author><author><name sortKey="Canning, E" uniqKey="Canning E">E Canning</name></author><author><name sortKey="Shaw, J" uniqKey="Shaw J">J Shaw</name></author><author><name sortKey="Ward, R" uniqKey="Ward R">R Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matos, E" uniqKey="Matos E">E Matos</name></author><author><name sortKey="Mendonca, I" uniqKey="Mendonca I">I Mendonca</name></author><author><name sortKey="Azevedo, C" uniqKey="Azevedo C">C Azevedo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adler, S" uniqKey="Adler S">S Adler</name></author><author><name sortKey="Mayrink, W" uniqKey="Mayrink W">W Mayrink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ayala, S" uniqKey="Ayala S">S Ayala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brazil, Rp" uniqKey="Brazil R">RP Brazil</name></author><author><name sortKey="Oliveira, Smp" uniqKey="Oliveira S">SMP Oliveira</name></author><author><name sortKey="Dias, Cmg" uniqKey="Dias C">CMG Dias</name></author><author><name sortKey="Andrade Filho, Jd" uniqKey="Andrade Filho J">JD Andrade Filho</name></author><author><name sortKey="Falcao, Al" uniqKey="Falcao A">AL Falcão</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, D" uniqKey="Lewis D">D Lewis</name></author><author><name sortKey="Lainson, R" uniqKey="Lainson R">R Lainson</name></author><author><name sortKey="Shaw, J" uniqKey="Shaw J">J Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, Ta" uniqKey="Klein T">TA Klein</name></author><author><name sortKey="Young, Dg" uniqKey="Young D">DG Young</name></author><author><name sortKey="Telford, Sr" uniqKey="Telford S">SR Telford</name></author><author><name sortKey="Kimsey, R" uniqKey="Kimsey R">R Kimsey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Killick Kendrick, R" uniqKey="Killick Kendrick R">R Killick-Kendrick</name></author><author><name sortKey="Killick Kendrick, M" uniqKey="Killick Kendrick M">M Killick-Kendrick</name></author><author><name sortKey="Quala, N" uniqKey="Quala N">N Quala</name></author><author><name sortKey="Nawi, R" uniqKey="Nawi R">R Nawi</name></author><author><name sortKey="Ashford, R" uniqKey="Ashford R">R Ashford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warburg, A" uniqKey="Warburg A">A Warburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poinar, G" uniqKey="Poinar G">G Poinar</name></author><author><name sortKey="Ferro, C" uniqKey="Ferro C">C Ferro</name></author><author><name sortKey="Morales, A" uniqKey="Morales A">A Morales</name></author><author><name sortKey="Tesh, R" uniqKey="Tesh R">R Tesh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Secundino, Nf" uniqKey="Secundino N">NF Secundino</name></author><author><name sortKey="Araujo, Ms" uniqKey="Araujo M">MS Araujo</name></author><author><name sortKey="Oliveira, Gh" uniqKey="Oliveira G">GH Oliveira</name></author><author><name sortKey="Massara, Cl" uniqKey="Massara C">CL Massara</name></author><author><name sortKey="Carvalho, Os" uniqKey="Carvalho O">OS Carvalho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Handelsman, J" uniqKey="Handelsman J">J Handelsman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Ca" uniqKey="Thomas C">CA Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Margulies, M" uniqKey="Margulies M">M Margulies</name></author><author><name sortKey="Egholm, M" uniqKey="Egholm M">M Egholm</name></author><author><name sortKey="Altman, We" uniqKey="Altman W">WE Altman</name></author><author><name sortKey="Attiya, S" uniqKey="Attiya S">S Attiya</name></author><author><name sortKey="Bader, Js" uniqKey="Bader J">JS Bader</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sudia, Wd" uniqKey="Sudia W">WD Sudia</name></author><author><name sortKey="Chamberlain, Rw" uniqKey="Chamberlain R">RW Chamberlain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bohlander, Sk" uniqKey="Bohlander S">SK Bohlander</name></author><author><name sortKey="Espinosa, R" uniqKey="Espinosa R">R Espinosa</name></author><author><name sortKey="Le Beau, Mm" uniqKey="Le Beau M">MM Le Beau</name></author><author><name sortKey="Rowley, Jd" uniqKey="Rowley J">JD Rowley</name></author><author><name sortKey="Diaz, Mo" uniqKey="Diaz M">MO Diaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Coscoy, L" uniqKey="Coscoy L">L Coscoy</name></author><author><name sortKey="Zylberberg, M" uniqKey="Zylberberg M">M Zylberberg</name></author><author><name sortKey="Avila, Pc" uniqKey="Avila P">PC Avila</name></author><author><name sortKey="Boushey, Ha" uniqKey="Boushey H">HA Boushey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox Foster, Dl" uniqKey="Cox Foster D">DL Cox-Foster</name></author><author><name sortKey="Conlan, S" uniqKey="Conlan S">S Conlan</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author><author><name sortKey="Palacios, G" uniqKey="Palacios G">G Palacios</name></author><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Jaroszewski, L" uniqKey="Jaroszewski L">L Jaroszewski</name></author><author><name sortKey="Godzik, A" uniqKey="Godzik A">A Godzik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Godzik, A" uniqKey="Godzik A">A Godzik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altschul, Sf" uniqKey="Altschul S">SF Altschul</name></author><author><name sortKey="Madden, Tl" uniqKey="Madden T">TL Madden</name></author><author><name sortKey="Schaffer, Aa" uniqKey="Schaffer A">AA Schaffer</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Garrity, Gm" uniqKey="Garrity G">GM Garrity</name></author><author><name sortKey="Tiedje, Jm" uniqKey="Tiedje J">JM Tiedje</name></author><author><name sortKey="Cole, Jr" uniqKey="Cole J">JR Cole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cole, Jr" uniqKey="Cole J">JR Cole</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Cardenas, E" uniqKey="Cardenas E">E Cardenas</name></author><author><name sortKey="Fish, J" uniqKey="Fish J">J Fish</name></author><author><name sortKey="Chai, B" uniqKey="Chai B">B Chai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fisher, R" uniqKey="Fisher R">R Fisher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volf, P" uniqKey="Volf P">P Volf</name></author><author><name sortKey="Kiewegova, A" uniqKey="Kiewegova A">A Kiewegova</name></author><author><name sortKey="Nemec, A" uniqKey="Nemec A">A Nemec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amann, Ri" uniqKey="Amann R">RI Amann</name></author><author><name sortKey="Ludwig, W" uniqKey="Ludwig W">W Ludwig</name></author><author><name sortKey="Schleifer, Kh" uniqKey="Schleifer K">KH Schleifer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Demaio, J" uniqKey="Demaio J">J Demaio</name></author><author><name sortKey="Pumpuni, Cb" uniqKey="Pumpuni C">CB Pumpuni</name></author><author><name sortKey="Kent, M" uniqKey="Kent M">M Kent</name></author><author><name sortKey="Beier, Jc" uniqKey="Beier J">JC Beier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Straif, Sc" uniqKey="Straif S">SC Straif</name></author><author><name sortKey="Mbogo, Cn" uniqKey="Mbogo C">CN Mbogo</name></author><author><name sortKey="Toure, Am" uniqKey="Toure A">AM Toure</name></author><author><name sortKey="Walker, Ed" uniqKey="Walker E">ED Walker</name></author><author><name sortKey="Kaufman, M" uniqKey="Kaufman M">M Kaufman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saw, Jh" uniqKey="Saw J">JH Saw</name></author><author><name sortKey="Mountain, Bw" uniqKey="Mountain B">BW Mountain</name></author><author><name sortKey="Feng, L" uniqKey="Feng L">L Feng</name></author><author><name sortKey="Omelchenko, Mv" uniqKey="Omelchenko M">MV Omelchenko</name></author><author><name sortKey="Hou, S" uniqKey="Hou S">S Hou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takami, H" uniqKey="Takami H">H Takami</name></author><author><name sortKey="Takaki, Y" uniqKey="Takaki Y">Y Takaki</name></author><author><name sortKey="Chee, Gj" uniqKey="Chee G">GJ Chee</name></author><author><name sortKey="Nishi, S" uniqKey="Nishi S">S Nishi</name></author><author><name sortKey="Shimamura, S" uniqKey="Shimamura S">S Shimamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bentley, Sd" uniqKey="Bentley S">SD Bentley</name></author><author><name sortKey="Chater, Kf" uniqKey="Chater K">KF Chater</name></author><author><name sortKey="Cerdeno Tarraga, Am" uniqKey="Cerdeno Tarraga A">AM Cerdeno-Tarraga</name></author><author><name sortKey="Challis, Gl" uniqKey="Challis G">GL Challis</name></author><author><name sortKey="Thomson, Nr" uniqKey="Thomson N">NR Thomson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilligan, Ph" uniqKey="Gilligan P">PH Gilligan</name></author><author><name sortKey="Lum, G" uniqKey="Lum G">G Lum</name></author><author><name sortKey="Vandamme, Par" uniqKey="Vandamme P">PAR Vandamme</name></author><author><name sortKey="Whittier, S" uniqKey="Whittier S">S Whittier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ryan, Mp" uniqKey="Ryan M">MP Ryan</name></author><author><name sortKey="Pembroke, Jt" uniqKey="Pembroke J">JT Pembroke</name></author><author><name sortKey="Adley, Cc" uniqKey="Adley C">CC Adley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruggemann, H" uniqKey="Bruggemann H">H Bruggemann</name></author><author><name sortKey="Henne, A" uniqKey="Henne A">A Henne</name></author><author><name sortKey="Hoster, F" uniqKey="Hoster F">F Hoster</name></author><author><name sortKey="Liesegang, H" uniqKey="Liesegang H">H Liesegang</name></author><author><name sortKey="Wiezer, A" uniqKey="Wiezer A">A Wiezer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leyden, Jj" uniqKey="Leyden J">JJ Leyden</name></author><author><name sortKey="Mcginley, Kj" uniqKey="Mcginley K">KJ McGinley</name></author><author><name sortKey="Vowels, B" uniqKey="Vowels B">B Vowels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iacono, M" uniqKey="Iacono M">M Iacono</name></author><author><name sortKey="Villa, L" uniqKey="Villa L">L Villa</name></author><author><name sortKey="Fortini, D" uniqKey="Fortini D">D Fortini</name></author><author><name sortKey="Bordoni, R" uniqKey="Bordoni R">R Bordoni</name></author><author><name sortKey="Imperi, F" uniqKey="Imperi F">F Imperi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dijkshoorn, L" uniqKey="Dijkshoorn L">L Dijkshoorn</name></author><author><name sortKey="Nemec, A" uniqKey="Nemec A">A Nemec</name></author><author><name sortKey="Seifert, H" uniqKey="Seifert H">H Seifert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Staudinger, T" uniqKey="Staudinger T">T Staudinger</name></author><author><name sortKey="Pipal, A" uniqKey="Pipal A">A Pipal</name></author><author><name sortKey="Redl, B" uniqKey="Redl B">B Redl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monteiro Vitorello, Cb" uniqKey="Monteiro Vitorello C">CB Monteiro-Vitorello</name></author><author><name sortKey="Camargo, Le" uniqKey="Camargo L">LE Camargo</name></author><author><name sortKey="Van Sluys, Ma" uniqKey="Van Sluys M">MA Van Sluys</name></author><author><name sortKey="Kitajima, Jp" uniqKey="Kitajima J">JP Kitajima</name></author><author><name sortKey="Truffi, D" uniqKey="Truffi D">D Truffi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costello, Ek" uniqKey="Costello E">EK Costello</name></author><author><name sortKey="Halloy, Sr" uniqKey="Halloy S">SR Halloy</name></author><author><name sortKey="Reed, Sc" uniqKey="Reed S">SC Reed</name></author><author><name sortKey="Sowell, P" uniqKey="Sowell P">P Sowell</name></author><author><name sortKey="Schmidt, Sk" uniqKey="Schmidt S">SK Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kudo, R" uniqKey="Kudo R">R Kudo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lainson, R" uniqKey="Lainson R">R Lainson</name></author><author><name sortKey="Killick Kendrick, R" uniqKey="Killick Kendrick R">R Killick-Kendrick</name></author><author><name sortKey="Canning, E" uniqKey="Canning E">E Canning</name></author><author><name sortKey="Shaw, J" uniqKey="Shaw J">J Shaw</name></author><author><name sortKey="Ward, R" uniqKey="Ward R">R Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goker, M" uniqKey="Goker M">M Göker</name></author><author><name sortKey="Voglmayr, H" uniqKey="Voglmayr H">H Voglmayr</name></author><author><name sortKey="Riethmuller, A" uniqKey="Riethmuller A">A Riethmüller</name></author><author><name sortKey="Weisz, M" uniqKey="Weisz M">M Weisz</name></author><author><name sortKey="Oberwinkler, F" uniqKey="Oberwinkler F">F Oberwinkler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khot, Pd" uniqKey="Khot P">PD Khot</name></author><author><name sortKey="Ko, Dl" uniqKey="Ko D">DL Ko</name></author><author><name sortKey="Fredricks, Dn" uniqKey="Fredricks D">DN Fredricks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seif, E" uniqKey="Seif E">E Seif</name></author><author><name sortKey="Leigh, J" uniqKey="Leigh J">J Leigh</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Roewer, I" uniqKey="Roewer I">I Roewer</name></author><author><name sortKey="Forget, L" uniqKey="Forget L">L Forget</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crous, Pw" uniqKey="Crous P">PW Crous</name></author><author><name sortKey="Braun, U" uniqKey="Braun U">U Braun</name></author><author><name sortKey="Schubert, K" uniqKey="Schubert K">K Schubert</name></author><author><name sortKey="Groenewald, Jz" uniqKey="Groenewald J">JZ Groenewald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crous, Pw" uniqKey="Crous P">PW Crous</name></author><author><name sortKey="Wingfield, Mj" uniqKey="Wingfield M">MJ Wingfield</name></author><author><name sortKey="Groenewald, Jz" uniqKey="Groenewald J">JZ Groenewald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashiguchi, Y" uniqKey="Hashiguchi Y">Y Hashiguchi</name></author><author><name sortKey="Gomez, E" uniqKey="Gomez E">E Gomez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Votypka, J" uniqKey="Votypka J">J Votypka</name></author><author><name sortKey="Lantova, L" uniqKey="Lantova L">L Lantova</name></author><author><name sortKey="Ghosh, K" uniqKey="Ghosh K">K Ghosh</name></author><author><name sortKey="Braig, H" uniqKey="Braig H">H Braig</name></author><author><name sortKey="Volf, P" uniqKey="Volf P">P Volf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dougherty, Mj" uniqKey="Dougherty M">MJ Dougherty</name></author><author><name sortKey="Ward, Rd" uniqKey="Ward R">RD Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soares, Rp" uniqKey="Soares R">RP Soares</name></author><author><name sortKey="Turco, Sj" uniqKey="Turco S">SJ Turco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morrison, Ac" uniqKey="Morrison A">AC Morrison</name></author><author><name sortKey="Ferro, C" uniqKey="Ferro C">C Ferro</name></author><author><name sortKey="Tesh, Rb" uniqKey="Tesh R">RB Tesh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jarvis, Ek" uniqKey="Jarvis E">EK Jarvis</name></author><author><name sortKey="Rutledge, Lc" uniqKey="Rutledge L">LC Rutledge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quinnell, R" uniqKey="Quinnell R">R Quinnell</name></author><author><name sortKey="Dye, C" uniqKey="Dye C">C Dye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prugnolle, F" uniqKey="Prugnolle F">F Prugnolle</name></author><author><name sortKey="Durand, P" uniqKey="Durand P">P Durand</name></author><author><name sortKey="Neel, C" uniqKey="Neel C">C Neel</name></author><author><name sortKey="Ollomo, B" uniqKey="Ollomo B">B Ollomo</name></author><author><name sortKey="Ayala, Fj" uniqKey="Ayala F">FJ Ayala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uetz, P" uniqKey="Uetz P">P Uetz</name></author><author><name sortKey="Hallermann, J" uniqKey="Hallermann J">J Hallermann</name></author><author><name sortKey="Hosek, J" uniqKey="Hosek J">J Hosek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luz, C" uniqKey="Luz C">C Luz</name></author><author><name sortKey="Tigano, M" uniqKey="Tigano M">M Tigano</name></author><author><name sortKey="Silva, I" uniqKey="Silva I">I Silva</name></author><author><name sortKey="Cordeiro, C" uniqKey="Cordeiro C">C Cordeiro</name></author><author><name sortKey="Aljanabi, S" uniqKey="Aljanabi S">S Aljanabi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratter, Ja" uniqKey="Ratter J">JA Ratter</name></author><author><name sortKey="Ribeiro, Jf" uniqKey="Ribeiro J">JF Ribeiro</name></author><author><name sortKey="Bridgewater, S" uniqKey="Bridgewater S">S Bridgewater</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Argentine</li></country></list><tree><country name="Argentine"><noRegion><name sortKey="Mccarthy, Christina B" sort="Mccarthy, Christina B" uniqKey="Mccarthy C" first="Christina B." last="Mccarthy">Christina B. Mccarthy</name></noRegion><name sortKey="Diambra, Luis A" sort="Diambra, Luis A" uniqKey="Diambra L" first="Luis A." last="Diambra">Luis A. Diambra</name><name sortKey="Mccarthy, Christina B" sort="Mccarthy, Christina B" uniqKey="Mccarthy C" first="Christina B." last="Mccarthy">Christina B. Mccarthy</name><name sortKey="Rivera Pomar, Rolando V" sort="Rivera Pomar, Rolando V" uniqKey="Rivera Pomar R" first="Rolando V." last="Rivera Pomar">Rolando V. Rivera Pomar</name><name sortKey="Rivera Pomar, Rolando V" sort="Rivera Pomar, Rolando V" uniqKey="Rivera Pomar R" first="Rolando V." last="Rivera Pomar">Rolando V. Rivera Pomar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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